The Amos family of Lawrence County started with the arrival of Asa and Nancy Amos in 1826. Asa Amos was born in Patrick County, Virginia on December 6, 1792. Nancy Amos was the daughter of John Hunter, and was born in Patrick County Virginia in 1798.

Asa Amos was a veteran of the War of 1812, having enlisted in a "volunteer rifle company" of the Virginia Militia on September 10, 1813. He served in the army for six months and was discharged in March 1914.

Asa and Nancy were married in Stokes County, North Carolina on Christmas Day, 1816. When they arrived in Ohio in 1826, they settled in the Greasy Ridge area of Mason Township in Lawrence County. While in Lawrence County, their sons James M., David, and William Covington Amos were born.

In 1830 the Amos family moved to a farm near the village of Patriot in Perry Township, Gallia County, Ohio. Here their children Polly, Mary Ann, Henry S., and Stephen D. Amos were born. Asa and Nancy lived out their lives in Gallia County. Asa died on May 31, 1880 at age 82. Nancy died in 1884. They are buried in the Salem Baptist Cemetery in Perry Township, Gallia County, Ohio.

Four of Asa's and Nancy's sons served in the Union Army during the Civil War. John and Stephen were members of the 18th. Ohio Battery. James was commissioned a lieutenant in the Ohio Militia, but died before he could be assigned to a regiment. Henry S. also served in the Ohio Militia, and died in a military hospital in Covington, Kentucky in 1861.

William Covington Amos and Stephen D. Amos eventually settled in Ironton. William married Harriet Elizabeth Sutton in the village of Etna Furnace in Elizabeth Township on November 26, 1857. Stephen Amos married Harriet's sister, Ella Sutton.

William C. Amos was known throughout his adult life as "Cub" Amos. Cub and Harriet had eight children: Martha Jane, Mary Rosalie, Nellie Florence, Horace Leftridge, Lillie Grace, Joanna, and two whose names remain unknown. Mary Rosalie married A. C. Thomas, Lillie Grace married William E. Delaney, and Horace Leftridge (known as "Lef" Amos) married Mette Ellison, the daughter of Dr. amd Mrs. Owen Ellison of Ironton.

Cub Amos was one of Ironton's leading citizens and was one of the pioneer iron men of the region. At various times he leased and managed Etna Furnace, Vesuvius Furnace, and Bloom Furnace, and was associated with John T. McKnight in the wholesale grocery business under the name of McKnight and Amos. The last furnace work in which he was engaged was for the Amos and Davis Iron Company in the management of Center Furnace.

William C. Amos died March 16, 1902. At the time of his death only two of his eight children were still living: Lillie Grace Amos Delaney and Horace Leftridge Amos. Harriet Amos died in February 1910. Cub and Harriet are buried in Woodlawn Cemetery, Ironton.